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Molecular Dynamics Analyses of Prion Protein Structures [[electronic resource] ] : The Resistance to Prion Diseases Down Under / / by Jiapu Zhang
| Molecular Dynamics Analyses of Prion Protein Structures [[electronic resource] ] : The Resistance to Prion Diseases Down Under / / by Jiapu Zhang |
| Autore | Zhang Jiapu |
| Edizione | [1st ed. 2018.] |
| Pubbl/distr/stampa | Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 |
| Descrizione fisica | 1 online resource (XXIX, 375 p. 596 illus., 278 illus. in color.) |
| Disciplina | 572.6 |
| Collana | Focus on Structural Biology |
| Soggetto topico | Proteomics |
| ISBN | 981-10-8815-2 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Preface -- Basic Knowledge -- Part I Prion Resistance Species -- Rabbits -Wild-type and Mutants -- Dogs -Wild-type and D159NMutant -- Horses, Buffaloes, and Pigs -- Chicken, Turtles, and Frogs -- Other Species -- Part II b 2-a2 Loop -- Wild-type Mouse 37 oC and 19.85 oC Structures -- Mouse Mutants -- Other Species with an Ordered b 2-a2 -- Part III Human Mutants -- Human Mutants -- Human PrPC Monomer, Dimer and Its M129V Mutant -- Human Peptides -- Part IV PrP Binding/Docking -- PrP Bounded to Antibodies, Nanobody, RNA aptamer, etc -- Potential Antiprion Drugs -- Part V Prion Peptides with Cross-b Structures -- Mathematical Formulas for All PrP Peptides’ cross-b structures -- Hydrogen Bonds Between Two Optimized Fundamental Chains of Each Model -- References. . |
| Record Nr. | UNINA-9910298603503321 |
Zhang Jiapu
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| Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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Molecular Structures and Structural Dynamics of Prion Proteins and Prions [[electronic resource] ] : Mechanism Underlying the Resistance to Prion Diseases / / by Jiapu Zhang
| Molecular Structures and Structural Dynamics of Prion Proteins and Prions [[electronic resource] ] : Mechanism Underlying the Resistance to Prion Diseases / / by Jiapu Zhang |
| Autore | Zhang Jiapu |
| Edizione | [1st ed. 2015.] |
| Pubbl/distr/stampa | Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015 |
| Descrizione fisica | 1 online resource (366 p.) |
| Disciplina | 616.83 |
| Collana | Focus on Structural Biology |
| Soggetto topico |
Proteins
Molecular biology Bioinformatics Chemistry, Physical and theoretical Biophysics Biological physics Protein Structure Molecular Medicine Computational Biology/Bioinformatics Theoretical and Computational Chemistry Biological and Medical Physics, Biophysics |
| ISBN | 94-017-7318-1 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | Basic Knowledge -- The Homology Structure and Dynamics -- The NMR Structure and Dynamics of the Wild-type and Mutants -- Compared with the NMR Structure and Dynamics of Humans and Mice -- Compared with the NMR Structure and Dynamics of Dogs and Horses -- Compared with a Homology Structure and Dynamics of Buffaloes -- Compared with NMR Structure and Dynamics of Elks -- Compared with the X-ray Structure and Dynamics of Rabbits -- Surface Electrostatic Charge Distributions -- The Hydrophobic Region PrP(109–136) -- The Hybrid Method of Steepest Descent - Conjugate Gradient with Simulated Annealing -- Hybrid Method of Discrete Gradient with Simulated Annealing or Genetic Algorithm -- A Novel Canonical Dual Global Optimization Computational Approach -- The Hybrid Method of Evolutionary Computations with Simulated Annealing -- Simulated Annealing Refined Replica Exchange Global Search Algorithm -- LBFGS Quasi-Newtonian Methods for MM Prion AGAAAAGA Amyloid Fibrils -- Particle Swarm Global Optimization Search Algorithm -- A Summary of the Research Works on AGAAAAGA. |
| Record Nr. | UNINA-9910298267303321 |
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Zhang Jiapu
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| Dordrecht : , : Springer Netherlands : , : Imprint : Springer, , 2015 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Optimization-based Molecular Dynamics Studies of SARS-CoV-2 Molecular Structures [[electronic resource] ] : Research on COVID- 19 / / by Jiapu Zhang
| Optimization-based Molecular Dynamics Studies of SARS-CoV-2 Molecular Structures [[electronic resource] ] : Research on COVID- 19 / / by Jiapu Zhang |
| Autore | Zhang Jiapu |
| Edizione | [1st ed. 2023.] |
| Pubbl/distr/stampa | Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2023 |
| Descrizione fisica | 1 online resource (956 pages) |
| Disciplina | 572.8 |
| Collana | Springer Series in Biophysics |
| Soggetto topico |
Biomolecules
Physical biochemistry Macromolecules Molecular biology Biophysics Proteins Bioinformatics Structural Biology Molecular Biology Molecular Biophysics Protein Biochemistry |
| ISBN |
9783031367731
9783031367724 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto | 1 Papain-Like cysteine protease (PLpro) -- 2 3C-Like protease (3CLpro) -- 3 RNA-dependent RNA polymerase (RdRp) -- 4 RNA-helicase -- 5 RNA-helicase binding with [RdRp, NSP7, NSP8a, NSP8b, pRNA, tRNA, ADP-Mg2+, ATP-Mg2+] -- 6 RNA-helicase binding with [ADP-Mg2+, ATP-Mg2+, and RNA] -- 7 Spike (S) glycoprotein -- 8 Spike (S) glycoprotein D614G mutant -- 9 Spike (S) glycoprotein N501Y mutant -- 10 Spike (S) glycoprotein N165A-and-N234A mutant -- 11 SARS (SARS-CoV-1) -- 12 MERS-coronavirus (MERS) -- 13 Human-ACE2, human-L6, human-L6R, human-nAChRs -- 14 PLpro binding with 12 compounds -- 15 3CLpro binding with N3/Lopinavir/Ritonavir -- 16 3CLpro dimer binding with 7 HIV-inhibitors and Others -- 17 Spike RBDs binding with 50 drugs -- 18 Human ACE2 ectodomain binding with 78 drugs -- 19 Spike-and-ACE2 binding with 100 drugs -- 20 Envelope protein (E-protein) -- 21 Membrane glycoprotein (M-protein) -- 22 Nucleocapsid phosphoprotein (N-protein) -- 23 SARS-CoV-2 RNA genome -- 24 NSP7, NSP8, NSP9, NSP10, NSP16, NSP14 -- 25 NSP15 -- 26 Other mutants -- 27 Vaccines and Drugs -- 28 Pandemic Mathematical Models, Epidemiology and Virus Origins -- A Mathematical Optimization Algorithms and Free Energy Calculations -- References -- Index. |
| Record Nr. | UNINA-9910751390203321 |
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Zhang Jiapu
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| Cham : , : Springer Nature Switzerland : , : Imprint : Springer, , 2023 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
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